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Results Semaglutide reached weight-loss plateau before achieving normal body weight DIO mice received semaglutide at its maximal efficacious dose (30 nmol/kg) for 3 weeks using dose escalation: Day 0 (0.3 nmol/kg/day)

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10.1186/S12933-021-01400-9/FIGURES/1 19 GiuglianoD.ScappaticcioL.LongoM.CarusoP.MaiorinoM

Some preliminary evidence suggests that meal distribution throughout the day may influence metabolic responses, though direct effects on GLP-1 secretion specifically require further research